Learning Center

Antifungal and Synergistic Effects of the Ethyl Acetate Extract of Tanacetum vulgare (L.) Against Candida albicans.

The EthOAc extract of T. vulgare may be a useful tool to discover natural bioactive agents that have antifungal activity against C. albicans and could be used as endodontic therapies.

Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer.

Preclinical studies have also shown that Tulsi and some of its phytochemicals eugenol, rosmarinic acid, apigenin, myretenal, luteolin, β-sitosterol, and carnosic acid prevented chemical-induced skin, liver, oral, and lung cancers and to mediate these effects by increasing the antioxidant activity, altering the gene expressions, inducing apoptosis, and inhibiting angiogenesis and metastasis.

Ocimum sanctum leaf extracts attenuate human monocytic (THP-1) cell activation.

Ocimum sanctum (OS), commonly known as Holy basil/Tulsi, has been traditionally used to treat cardiovascular diseases (CVD) and manage general cardiac health. The present study is designed to evaluate the antiinflammatory effect of O. sanctum and its phenolic compound and eugenol (EUG) in human monocytic (THP-1) cells and validate its traditional use for treating cardiovascular diseases.

Triphala Suppresses Growth and Migration of Human Gastric Carcinoma Cells In Vitro and in a Zebrafish Xenograft Model.

Triphala is a promising antineoplastic agent for the treatment of gastric carcinomas with significant antiproliferative and antimetastatic activities.

Antibacterial and Cytotoxic Effects of Moringa oleifera (Moringa) and Azadirachta indica (Neem) Methanolic Extracts against Strains of Enterococcus faecalis. 

We demonstrated that the methanolic extract of Azadirachta indica and Moringa oleifera both have an antibacterial effect against Enterococcus faecalis strains during the first 24 and 48 hours.

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders.

Triphala holds potential in improving lower GI symptoms and may be a valuable and effective addition to standard treatment of IBS. Supplementation of TLP herbal formulations alone or along with other probiotics can be recommended in ongoing clinical studies.

Antimicrobial effect of herbal extract of Acacia arabica with triphala on the biofilm forming cariogenic microorganisms.

The anti-adherence and anti-biofilm effect as well as the faster killing activity suggests that a mixed herbal powder extract formula has effective antibacterial activity and could be a useful source of anti-carcinogenic agents in near future.

Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. 

Oral administration of E. ribes (common name: vidanga) ethanolic extract in dose of 100 mg/kg and 200 mg/kg significantly reduced the levels of blood glucose, glycated haemoglobin, heart rate (HR) and systolic blood pressure (SBP) in animals when compared with diabetic rats.

Antimicrobial efficacy of plant essential oils and extracts against Escherichia coli.

They may also be useful in applications in which other antimicrobials have reduced efficacy (e.g., in the presence of organics) or used with sensitive populations that are unable to tolerate exposure to harsh chemicals (e.g., elderly care facilities). These compounds could be used alone, in combination, or with fast-acting antimicrobials to provide a long-lasting residual.

Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics.

Triphala interfered with reassembly of the microtubules. Cells treated with Triphala eventually underwent programmed cell death as evidenced by annexin-V staining. Our study shows that the effect of aqueous extract of Triphala is potent enough to interfere with the assembly dynamics of microtubules, and that Triphala can be investigated further for its antitumor potential.

Potential Alternative Treatment of Ocular Bacterial Infections by Oil Derived from Syzygium aromaticum Flower (Clove).

The current study showed that S. aromaticum oil had high antibacterial activity that could be helpful in the treatment of ocular bacterial infections to minimizing the possible side effects of commonly used antibiotic.

Prospects for Therapeutic Mitochondrial Transplantation

New and compelling research investigating novel techniques for mitochondrial transplantation to replace damaged or dysfunctional mitochondria with exogenous healthy mitochondria has shown promising results, including tissue sparing accompanied by increased energy production and decreased oxidative damage.

The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis.

Targeting oxidative stress and mitochondrial dysfunction might serve as a therapeutic point of intervention against cholestasis-associated organ injury.

Autophagy, Apoptosis, and Mitochondria: Molecular Integration and Physiological Relevance in Skeletal Muscle.

Apoptosis and autophagy are processes resulting from the integration of cellular stress and death signals. their intertwined relationship means that dysfunction can promote pathology.